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#Astrocyte

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Matt Willemsen

Alzheimer’s Breakthrough: New Blood Biomarker Discovered
By testing the blood of more than 1,000 cognitively unimpaired elderly people with and without amyloid pathology, the Pitt-led research team found that only those who had a combination of amyloid burden and blood markers of abnormal astrocyte activation, or reactivity, would progress to symptomatic Alzheimer’s in the future, a critical discovery for drug development aimed at halting progression.
scitechdaily.com/alzheimers-br #BloodBiomarker #astrocyte #amyloid

SciTechDailyAlzheimer’s Breakthrough: New Blood Biomarker DiscoveredWhat determines whether an individual will develop Alzheimer's disease, and why do many with the disease's characteristic toxic amyloid accumulations in the brain never exhibit associated dementia symptoms? These perplexing questions have long puzzled researchers. Scientists from the University o
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Andrew Plested

For the #astrocyte crowd?

Exclusive early bird price just for you -Recycling 2023
Dear Colleague‍ ,

I would like to take the privilege to invite you to be an honorable speaker and deliver a presentation at 2nd International Conference and Expo on Recycling and Waste Management during 26-27 June, 2023 at Paris, France. If possible, I would appreciate receiving your abstract submission on or before May. 20. 2023.

#AcademicSpam
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Javier Díaz-Nido

Alzheimer’s Drug Lecanemab Shields Brain from Free-Roaming Amyloid Fibrils

Amyloid beta protein forms small aggregates that disrupt brain function in Alzheimer’s disease.
Lecanemab, a recently FDA-approved Alzheimer’s treatment, can neutralize these disruptive aggregates, hinting at its potential to slow down the disease’s cognitive decline.

#Neuroscience #Brain #Neurology #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Astrocyte #Neuron #Alzheimer #CognitiveDecline #CognitiveDysfunction #MemoryLoss #BetaAmyloid #AmyloidFibrils #Immunotherapy #Lecanemab

neurosciencenews.com/amyloid-f

Neuroscience NewsAlzheimer's Drug Lecanemab Shields Brain from Free-Roaming Amyloid Fibrils - Neuroscience NewsNeuroscience News provides research news for neuroscience, neurology, psychology, AI, brain science, mental health, robotics and cognitive sciences.
Public
Hari Tulsidas

A new study has revealed that astrocytes, a type of brain cell, can turn into neurons and restore memory in mice with Alzheimer’s disease. Astrocytes are star-shaped glial cells that support and protect neurons. The study found that activating a gene called Ascl1 in astrocytes can reprogram them into functional neurons and reverse cognitive decline. The study offers a potential new strategy for treating Alzheimer’s disease.

#astrocyte #neuron #Alzheimer’s

neurosciencenews.com/astrocyte

Public
Javier Díaz-Nido

Imaging Study Implicates Reactive Astrocyte-Neuron Interaction in Alzheimer’s Cognitive Decline

PET imaging with 11C-acetate and 18F-FDG was used to visualize the reactive astrocyte-induced acetate hypermetabolism and associated neuronal glucose hypometabolism in brains with neuroinflammation and Alzheimer’s Disease.

#Neuroscience #Brain #Neurology #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Astrocyte #Neuron #Alzheimer #BrainImaging #Neuroimaging #NeuroMetabolism #AcetateHypermetabolism #GlucoseHypometabolism #NeuroInflammation #CognitiveDecline #CognitiveDysfunction

genengnews.com/topics/drug-dis

GEN - Genetic Engineering and Biotechnology NewsImaging Study Implicates Reactive Astrocyte-Neuron Interaction in Alzheimer’s Cognitive DeclineBy Sophia Ktori
Public
Phys.org

Referenced link: medicalxpress.com/news/2023-04
Discuss on discu.eu/q/https://medicalxpre

Originally posted by Phys.org / @physorg_com: nitter.platypush.tech/medical_

RT by @physorg_com: A new breakthrough in Alzheimer's disease research: Visualizing reactive #astrocyte-neuron interaction academic.oup.com/brain/advance medicalxpress.com/news/2023-04

Medical XpressA new breakthrough in Alzheimer's disease research: Visualizing reactive astrocyte-neuron interactionBy Science X
Public
Danai Riga

For the #astrocyte lovers out there: fantastic new work from Aina Badia et al., showing ezrin-mediated PAP retraction in fear learning!
Such.Pretty.Data ❤️😍🌟

Retraction of Astrocyte Leaflets From the Synapse Enhances Fear Memory - Biological Psychiatry
biologicalpsychiatryjournal.co

Biological PsychiatryRetraction of Astrocyte Leaflets From the Synapse Enhances Fear MemoryThe formation and retrieval of fear memories depends on orchestrated synaptic activity of neuronal ensembles within the hippocampus, and it is becoming increasingly evident that astrocytes residing in the environment of these synapses play a central role in shaping cellular memory representations. Astrocyte distal processes, known as leaflets, fine-tune synaptic activity by clearing neurotransmitters and limiting glutamate diffusion. However, how astroglial synaptic coverage contributes to mnemonic processing of fearful experiences remains largely unknown.
Public
Alan R Kay

An integrated theory for #astrocyte function in #brain circuits and behavior
arxiv.org/abs/2211.09906

arXiv.orgContextual guidance: An integrated theory for astrocytes function in brain circuits and behaviorThe participation of astrocytes in brain computation was formally hypothesized in 1992, coinciding with the discovery that these glial cells display a complex form of Ca2+ excitability. This fostered conceptual advances centered on the notion of reciprocal interactions between neurons and astrocytes, which permitted a critical leap forward in uncovering many roles of astrocytes in brain circuits, and signaled the rise of a major new force in neuroscience: that of glial biology. In the past decade, a multitude of unconventional and disparate functions of astrocytes have been documented that are not predicted by these canonical models and that are challenging to piece together into a holistic and parsimonious picture. This highlights a disconnect between the rapidly evolving field of astrocyte biology and the conceptual frameworks guiding it, and emphasizes the need for a careful reconsideration of how we theorize the functional position of astrocytes in brain circuitry. Here, we propose a unifying, highly transferable, data-driven, and computationally-relevant conceptual framework for astrocyte biology, which we coin contextual guidance. It describes astrocytes as contextual gates that decode multiple environmental factors to shape neural circuitry in an adaptive, state-dependent fashion. This paradigm is organically inclusive of all fundamental features of astrocytes, many of which have remained unaccounted for in previous theories. We find that this new concept provides an intuitive and powerful theoretical space to improve our understanding of brain function and computational models thereof across scales because it depicts astrocytes as a hub for circumstantial inputs into relevant specialized circuits that permits adaptive behaviors at the network and organism level.
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eSagan 🇮🇳

**Glial Cells**
The human brain contains 86B neurons and 85B Glia.

**Different types of Glia:**

🔸 Astrocytes: Astrocytes are really important type of Glia. They're essentially responsible for keeping the environment clean, they're the sanitation worker of the brain. So they are picking up all the refuse that the neurons have let loose including excess ions, excess #neurotransmitters and their metabolites.

They also are very important during development. They allow neurons to get to where they have to go during development. #Neurons are born in one place and they have to go some place else, and what highway did they take? They hitch on a progenitor cell that is going to become an #Astrocyte.

And, in addition when synapses are formed, the synapses are not maintained without some effort, and part of that is that the synapses are enveloped in the processes of #Astrocytes. So, there's a lot of structural and metabolic support that the Astrocytes are providing for neurons.

🔸 Oligodendrocytes and Schwann Cells: The #oligodendrocytes make myelin in the CNS and the #SchwannCells make it in the Peripheral Nervous System. So all these demyelinating diseases will affect either central myelin or peripheral #myelin. They will not affect both -- central or peripheral.

Because they are made by two different types. The Oligodendrocytes in the central nervous system and a Schwann cells in the peripheral nervous system.

🔸 Microglia: #Microglia are the one exception to the rule that
nervous system, that the cells of the nervous system come from Ectoderm. These are actually essentially immune cells coming from the blood lineage. These are immune cells that have invaded into the central nervous system and their job is to be quiet. And if we're healthy and everything goes well, they are quiet. But when there is a problem these microglia react, they try to rectify things, they try and bring some attention to areas of damage and what is emerging is that sometimes they go overboard and they start to participate in making the problem as well as solving the problem.

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