Scientists make surprise finding on what causes Huntington’s disease
New research shows that the mutation is harmless for decades, but it quietly grows into a larger mutation and eventually crosses a threshold, generating toxic proteins.
#science #health #disease #research #HuntingtonsDisease #Huntingtons
https://globalnews.ca/news/10964360/huntington-disease-cause-new-study/
new paper: "A collaborative network analysis for the interpretation of transcriptomics data in Huntington’s disease" https://doi.org/10.1038/s41598-025-85580-4
"our study shows that collaborative network analysis approaches are well-suited to study rare diseases, as they provide hypotheses for pathogenic mechanisms from multiple perspectives."
"Exon skipping only works if the resulting protein is still functional, so it can't treat every disease with a genetic basis. That's the overall limitation of the approach," noted Professor Pablo Perez-Pinera.
"But for diseases like #Alzheimer's, #Parkinson's, #Huntingtons, or Duchenne's muscular dystrophy, this approach holds a lot of potential."
#genetics #health #medicine #biotechnology #research #science #biology
Been on a punk rock kick for the last few days. These two albums have gotta be some of the best in the genre! 
With organoids, researchers aim to bridge the gaps in knowledge that arise from using animals. These are simplified, miniaturized models of human organs that are created by genetically altering cells. Now, they have provided unexpected new insights into Huntington's disease.
#research #biology #Huntingtons #disease #genetics #medicine #health
Since everyone else is doing it.
Nothing extremely surprising to me here, except for "New York" making an appearance (I don't remember listening to that at all, so I'm not sure how it ended up in my top 5 songs).
The #Huntingtons just finished playing my all-time favorite song by them: "Losing Penny"
The #Huntingtons have not lost a step in 25 years. They are kicking ass. I'm so glad we had the opportunity to see them in concert again.
Canadian singer-songwriter Richard Laviolette, who left an indelible mark on his country's music landscape, died peacefully on Sept. 5 at 41, having chosen #MedicalAssistanceInDying in the wake of debilitating deterioration from #Huntingtons disease.
https://exclaim.ca/music/article/guelph_singer-songwriter_richard_laviolette_has_died
In case there's anyone here that might be interested, and didn't see the news on FB, #GhotiHook and The #Huntingtons are playing a show together in Millersville, PA in October.
Colder temps may help clear
Misfolded proteins of old age
Hope for new futures?
#coldtemps #aging #alzheimers #als #huntingtons #haiku #poetry
The first indication of a possible link between #MyalgicEncephalomyelitis and #CNS diseases:
“However, one new association was found, with the gene #PDE10A, which is implicated in #CentralNervousSystem diseases, such as #Parkinsons and #Huntingtons disease. This association has never been seen before, and would require replication in a new cohort before its role in #MECFS could be confirmed.“
https://era.ed.ac.uk/bitstream/handle/1842/39763/DibbleJJ_2022.pdf?sequence=1&isAllowed=y
Looking for more Clinically Vulnerable people / households on Mastodon.
Please add more # s to help us! 
& 
#MultipleSclerosis #MS
#MotorNeumotoDisease #MND
#Huntingtons #MyastheniaGravis
#CerebralPalsy
#LearningDisabilities
#Steroids #Biologics #Chemo #Chemotherapy #Radiotherapy
#Alzheimers
#Dementia
#Bipolar
#Asthma #COPD
#Cancer
#Diabetes #T1 #T2 #LADA #GestationalDiabetes
#Chrons #Colitis
#Epilepsy
#HeartDisease
#MentalHealth
#Parkinsons
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